It is well known that zinc is an essential element for life. It takes part in a variety of important metabolisms in biological systems in the form of zinc containing metalloen-zymes. In the past decade, it found that zinc is also involved in the gene transcription,duplication and protein synthesis processes as a regulator and mediator. Till now,a number of zinc proteins have been charcterized such as zinc finger,zinc twist,zinc ribbon and zinc cluster. Among them the zinc-metallothionein, Zn₇-MT is one of the well known zinc-cluster protein which is suggested palying a crucial role in the zinc homeostasis. It is very possible that zinc occupies the central part in controlling the growth and development of organisrns by means of successive regulation of MT and zinc finger proteins. In addition，it was found that some of regulation protein binding to oncogene and human immunedeficiency virus also contains zinc finger amino acid sequence，that will open a new field to fight against cancer and aids diseases.