Free radicals,a type of oxidants,cause various damage to organisms. The free radical hypothesis of aging is one of the theories about aging mechanism. Mitochondrial DNA,which has a special organization and structure,is prone to be attacked by free radicals.Now the oxidative damage of mitochondrial DNA is thought as the molecular basis of senescence causing by free radicals.
Zeng Zhaohui, Zhang Zongyu. The Oxidative Damage of Mitochondrial DNA by Free Radicals and Aging[J]. Progress in Biochemistry and Biophysics,1995,22(5):429-432
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