The initiation of translation is very important in the process of protein synthesis. On the major eukaryotic mRNAs template,initiation of translation is completed by a capdependent mechanism. Recent works demonstrate:a set of animal viruses mRNAs appear to have a different initiation mode based on a cap-independent internal initiation mechamsm.These mRNAs contain some conserved secondary structure in 5′untranslated region.Some specific protein factors can stimulate translation through the conserved site.
Li Tong, Wang Enduo. Internal Initiation of Eukaryotic mRNA Translation[J]. Progress in Biochemistry and Biophysics,1995,22(6):494-498
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