At present, more and more people are interested in studying the interaction between the receptors and their RGD-containing ligands. It is generally thought that the interaction between integrins and adhesive proteins is mediated through the RGD sequence within the adhesive proteins, which may participate in many physiologic process. A major description is given on the interaction between RGD-containing peptide and GpⅡb /Ⅲa and its inhibition on platelet aggregation. Also presented is the perspective of RGD-containing peptides or proteins in the study of the relationship of the structure and function of protein and in the pharmaceutical field.