By use of the AR-CM-MIC system and other methods, the relationship between cellular viability of alveolar macrophages and the change of intracellular Ca2+ concentration([Ca2+]i) after the action of verapamil was investigated under different extracellular calcium concentrations. And the research about the effect of verapamil on experimental silicosis rats were conducted. The results showed: the [Ca2+]i rise induced by α-quartz was caused by enormous extracellular Ca2+ influx and the overloading of the intracellular Ca2+, which directly led to the death of alveolar macrophages and further the formation of silicosis. Verapamil could inhibit the [Ca2+]i rise, decline the death of cells. The results of the research about experimental silicosis indicated: verapamil has apparent inhibitory effect on the starting of silicosis. It suggested that verapamil appears to be a prevention and cure drug of silicosis.
ZHU Wei-hua, WANG Jin-xi, LI Hai-shan, CHEN Yao. Research of Antagonism of Verapamil to the Cytotoxicity Induced by α-Quartz[J]. Progress in Biochemistry and Biophysics,1998,25(5):439-443
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