Cloning, Sequencing of Human Membrane Cofactor Protein (MCP) and Comparison with Other Isoforms
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    Abstract:

    MCP is an important membrane protein for protecting host cells from damage by complement because of its wide tissue distribution and cofactor activity. A human MCP cDNA containing full encoding region was obtained by RT-PCR from Chinese human embryo. The target gene was cloned and sequenced. The data indicated that there are forty-five bases deletion compared with the counterparts previouly reported,which leads to the deletion of fifteen amino acid residues. The PCR product including 369aa open reading frame was one of the ten isoforms which had been reported before and it was named MCP-C2.

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HUANG Jian, LI Wen-Xin, GOU De-Ming, JIANG Da-He. Cloning, Sequencing of Human Membrane Cofactor Protein (MCP) and Comparison with Other Isoforms[J]. Progress in Biochemistry and Biophysics,1999,26(4):355-358

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History
  • Received:March 02,1998
  • Revised:June 22,1998
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