In recent years, the effects of the N-methyl-D-aspartate(NMDA) receptor on the long-term potentiation(LTP) and the intracellular cascade reaction after the activation of the NMDA receptor are emphasised widely by people through antagonists and gene knockout technique. These studies show the processeing of induction and maintenance of the LTP. The results provide evidences for the pre- and post-synaptic mechanism of the LTP.