The physiological actitivities of organ and cell are affected significantly by mechanical stimulation. Although cells have different responses to each kind of mechanical stimulus, the mechanism of mechanosense are almost similar. First, the mechanical stimulus was sensed by cell membrane or integrin-cytoskeleton, then G protein and other signal molecules were activated, and finally some physiological or pathological effects were caused. So G protein may play a central role in the process of mechanical energy transforming to chemical energy.