Keratinocyte growth factor(KGF),a member of fibroblast growth factor(FGF),exerts proliferative and differenting effects on a variety of epithelial cells via binding to a specific FGF receptor. KGF gene expression is subject to positive and negative regulation. A fine balance of the regulation is important for normal function of KGF. Results have suggested that KGF play important roles in several aspects: the development of tissues and organs; prevent wound and facilitate wound healing; involvement in tissues malignant transformation.