In order to evaluate the role of inherited variation in the BRD7 gene in human nasoparyngeal carcinoma. RT-PCR, SSCP and sequencing were used to identified multiple coding-region single nucleotide polymorphisms (cSNPs), three cSNPs in BRD7 were found in fifty-seven sporadic biopsy specimens and corresponding blood samples from the same NPC patients and two pedigrees of NPC family. One of those cSNPs is A538C transition, which creates a missense change of Asp162Ala in three of NPC patients analyzed and three of fifty healthy individuals. Adjacent to the bromodomain (504～609 nt), another SNP (C450T) behind the start condon (484nt) results in a G133Ter substitution in 87.7% NPC biopsies and corresponding blood samples, all affected family members in the pedigrees and eight of nine susceptible members, the third SNP is synonymous polymorphism (A737G) which is coupled interestingly with the C450T alteration. The latter two forms of SNPs are also observed in eleven of fifty control normal blood samples. This findings suggest that the presence of the two coupled SNPs in BRD7 might be one of important risk factors for the development and/or progression of NPC (P＜0.01), and the BRD7 gene might have two modes of translation and the terminational SNP at 450 nt in BRD7 gene results in the second alternatively truncated isoform.