Membrane-associated guanylate kinase family proteins mediate the clustering and aggregation of ion channels,receptors and cell adhesion molecules via their PDZ、SH₃、GK domains,respectively. MAGUKs construct the cytoskeleton, take part in the signal transduction and modulate the cell cycle process,as well as the neural development. The characters of MAGUKs'structure ,their functions and some members of the family were explicated.