Effect of Acetaldehyde on Phosphorylation of Human Neuronal tau

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Effect of Acetaldehyde on Phosphorylation of Human Neuronal tau
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Fund Project:This work was supported by grants from the National Natural Foundation of Sciences (39970236) and National Key Foundation of Development and Research (G1999054007).

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Abstract:

Human neuronal tau-40 was acetylated and then phosphorylated by neuronal cdc2-like kinase (NCLK) with ［γ-³²P］ ATP, and then the phosphorylated acetyl-tau (PAtau) was digested with pepsin. Compared with the phosphorylated tau (Ptau), two new fractions of radioactivity from PAtau were obtained as it was eluted by C-18 column on HPLC.

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HUA Qian, NIE Chun-Lai, CHEN Yong-Hui, ZHANG Dai, HE Rong-Qiao. Effect of Acetaldehyde on Phosphorylation of Human Neuronal tau[J]. Progress in Biochemistry and Biophysics,2001,28(5):761-763

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Received:April 29,2001
Revised:July 05,2001
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