Annexin Ⅰ belongs to the annexins protein superfamily that comprises a multigene family of Ca²⁺ and phospholipid binding proteins. Annexins consist of a conserved C-terminal or core domain that confers Ca²⁺-dependent phospholipid binding and an N-terminal domain that is variable in sequences and length and responsible for the specific properties of each annexin. Annexin Ⅰ is one of the structurally related，calcium-dependent，phospholipid-binding proteins that have been implicated in diverse cellular roles, including anti-inflammatory, signal transduction, cell differentiation，membrane aggregation，inhibiting the activity of cytosolic phospholipase A2，calcium channels and interaction with cytoskeletal proteins.