This work was supported by grants from The National Natural Sciences Foundation of China (30070034,30025003) and The Chinese Academy of Sciences Knowledge Innovation Programs (kscx2-sw-302).
Baculoviruses are host specific for insects. The recent researches indicated that baculoviruses could entry into different mammalian cells, but do not replicate. The baculoviruses have been successfully used to deliver foreign DNA into mammalian cells in vitro and in vivo and efficiently mediated the expression of interest genes. These results indicated that baculovirus could be developed as potential gene therapy vectors. The recent development and prospects on using baculoviruses as target gene delivered vectors in gene therapy is reviewed.
LIANG Chang-Yong, HU Zhi-Hong, CHEN Xin-Wen. The Development of Baculoviruses as Novel Gene Therapy Vectors[J]. Progress in Biochemistry and Biophysics,2002,29(6):860-862
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