Skeleton is mainly composed of two different tissues: bone and cartilage. Recent studies show that Cbfa1 is not only a key regulator controlling bone formation and growth, but also important in cartilage maturation. And it may also be involved in osteoclastogenesis and cartilage vascular invasion.
LIU Wen-Guang, WANG Hong-Zhen, ZENG Xian-Lu. Cbfa1 in Skeleton Formation and Growth[J]. Progress in Biochemistry and Biophysics,2003,30(1):27-31
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