Application of Bioinformatics in Full-length cDNA Sequence Analysis and Function Prediction of Novel Genes

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Application of Bioinformatics in Full-length cDNA Sequence Analysis and Function Prediction of Novel Genes
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Fund Project:This work was partially supported by grants from State 863 High Technology R & D Project of China,National Science Fund for Distinguished Young Scholars(30128010),The National Natural Science Foundation of China(30100049,39900041 and 39900074),The Natural Scienec Foundation of Beijing(7002030),Initiative Foundation for Scientific and Technological Innovation of Academic Military Medical Science(0102001 and 9905105).

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Abstract:

Detection and analysis of differentially-displayed genes is a routine strategy for the study of different biological phenotype.A data-mining flowchart on the bioinformatic analysis of these genes is described,which includes sequence similarity analysis based on internet, contig assembly and full-length cDNA sequence obtaining.Moreover,the strategy for how to construct a local bioinformatic platform for large-scale analysis on novel genes is also introduced.All of this information will accelerate the progress on novel genes cloning and function prediction.

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ZHANG Cheng-Gang, HE Fu-Chu. Application of Bioinformatics in Full-length cDNA Sequence Analysis and Function Prediction of Novel Genes[J]. Progress in Biochemistry and Biophysics,2003,30(1):159-163

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Received:May 28,2002
Revised:August 06,2002
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