Epithelial surfaces of the upper alimentary tract and upper respiratory tract are swarming with protein compounds that protect itself from many kinds of damages. These compounds are consisted of innate immune molecules. From the structure and functional predication, the new member is added, plunc family, to the compounds. They are located at a narrow area less than 300 kb of human chromosome 20, including at least eight members. All the members of the family have the BPI domain and a signal peptide at the N-terminal. The sequences are highly conserved in human, mouse and rat, each expressed at the different sites of the airway epithelial, tongue, von Ebner gland and parotid gland. Some of them can be detected in the nasal lavage fluid. They may function to protect epithelial surfaces from pathogenic micro-organism and harmful gases, the wrong expression will lead to host tissues destruction and tumorigenesis.