Palladin is a novel actin-associated protein, its distribution is ubiquitous in smooth muscle ， central nervous system and embryonic tissues. It seems that palladin is required for the establishing/maintaining actin cytoskeleton and its dynamic assembly. Palladin colocalizes with alpha-actinin in actin cytoskeleton. Findings show that palladin play a critical role in controlling cell shape, cell migration or movement. Palladin expression is upregulated in metastatic cancer cells and astrocytes following traumatic injury to the central nervous system. Palladin upregulation allows the astrocytes to form the glial scar.