Parkin is a causative gene of autosomal recessive juvenile parkinsonism. Now it is believed that Parkin functions as an E3 ubiquitin protein ligase which involves in protein's ubiquitination. Parkin defect makes its substrates accumulate, which eventually leads to dopaminergic neuron selective death. More and more evidence shows that Parkin can protect neurons from various neuron toxic stimulations and may participate in the formation of Lewy body, therefore Parkin may be important in the pathogenesis of sporadic Parkinson's disease.