Based on the characteristics of base distribution in promoter and non-promoter region the method of Increment of Diversity with Quadratic Discriminant analysis (IDQD) was used to predict the pol Ⅱ promoter in human genome. The prediction has attained accuracy higher than 90%. The transcription start sites have also been predicted successfully with sensitivity 86% and specificity 91%, better than other top softwares currently published.
Lü Jun, LUO Liao-Fu. Human pol Ⅱ Promoter Prediction[J]. Progress in Biochemistry and Biophysics,2005,32(12):1185-1191
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