This work was supported by grants from Hong Kong Polytechnic University and National Key Laboratory of Traditional Chinese Medicine and Molecular Pharmacology (Shenzhen) (G-YX14, G-YD78, ASD-A256, G-YE07, GU-145,G-T616 and G-T856).
Hemojuvelin (HJV) is a newly discovered regulating protein of iron metabolism. Recent studies demonstrated that human mutation in the HJV gene is one of the causes for Juvenile hemochromatosis (Type Ⅱ hereditory hemochormatosis). New findings also indicated that HJV might be a regulator of hepcidin expression and thus play an essential role in iron homeostasis.
QIAN Zhong-Ming, WANG Qin, XU You-Jia, KE Ya. Hemojuvelin(HJV): A Newly Discovered Regulating Protein of Iron Metabolism[J]. Progress in Biochemistry and Biophysics,2006,33(3):226-230
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