This work was supported by a grant from National Basic Research Program of China (2003CB715900), Hi-Tech Research and Development Program of China (2006AA020403) and The National Natural Science Foundation of China (30770498).
Subcellular localization is a key characteristic of protein functional research. Proteins are transported to specific compartment after they are synthesized in cells. They can take part in the cell activity and function efficiently when in correct subcellular location. Sequence homolog, protein-protein interaction information and traditional amino acid composition are combined as input parameters of support vector machine (SVM) to predict eukaryotic protein subcellular localization. The total accuracy of 5-fold cross validation is 91.8%, which is higher than other methods.
ZHANG Song, XIA Xue-Feng, SHEN Jin-Cheng, SUN Zhi-Rong. Eukaryotic Protein Subcellular Localization Prediction Based on Sequence Conservation and Protein-Protein Interaction[J]. Progress in Biochemistry and Biophysics,2008,35(5):531-535
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