This work was supported by grants from The National Natural Science Foundation of China (30700958), Scientific Reaesrch Foundation for Medicine and Health from Health Bureau of Zhejiang Province (2007A131)
Osteoclastic bone resorption and osteoblastic bone formation are coordinated as a coupled mechanism to effect the development of bone and to maintain bone homeostasis. Recently reported Eph/ephrin bidirectional signaling between osteoclasts and osteoblasts plays a pivol role in bone homeostasis and casts new light on coupling of bone resorption and bone formation, which is gaining more and more attention in researches of bone biology and bone diseases. The present article aims to address the researches on the Eph/ephrin bidirectional signaling between osteoblasts and osteoclasts with molecular constitution, mechanism of the signal transduction, biological significance and so on.
ZHAO Juan, MAO Ying-Jie, GU Zhi-Yuan. Progress in Researches of Eph/ephrin Signaling in Coupling of Bone Resorption and Bone Formation[J]. Progress in Biochemistry and Biophysics,2009,36(9):1101-1105
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