This work was supported by grants from National Basic Research Program of China (2007BC507403), The National Natural Science Foundation of China (30672205, 30871440, 30971620), Guangdong Natural Science Foundation (8452402301001450), Key Foundation of Natural Science Research for Guangdong Universities (06Z015) and Science Technology Program of Bid Invitation of Zhanjiang (ZZ0605)
Epigenetics refers to non-coding sequence changes such as DNA methylation, histone modifications, chromosome remodeling and non-coding RNA regulation. Histone modifications include acetylation, phosphorylation, methylation, ubiquitination and ADP ribosylation. The combinations of different histone modifications, known as "histone code", are dynamic during development and differentiation and play important roles in the regulation of gene expressions in spatial-temporal manners. The modification on a particular residue in a histone affects not only the modifications at different residues in its own protein but also other histones. The histone modifications is a complicated network and the regulation remains elusive.
JIANG Zhi-Wen, LIU Xin-Guang, ZHOU Zhong-Jun. The Regulation of Histone Modifications[J]. Progress in Biochemistry and Biophysics,2009,36(10):1252-1259
Copy® 2024 All Rights Reserved ICP:京ICP备05023138号-1 京公网安备 11010502031771号