DJ-1 and parkinson′s disease

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DJ-1 and parkinson′s disease
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Fund Project:This work was supported by grants from National Basic Research Program of China (2010CB529704), Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) (IRT0731), Key Project of Joint Fund of Natural Science Foundation of China and Guangdong Province (U0632004), The National Natural Science Foundation of China (30670828, 30572151), Science and Technology Planning Project of Guangdong Province (07117506) and Science and Technology Planning Project of Guangzhou City (2007J1-C0301)

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Abstract:

Located in the cytoplasm, mitochondria and nucleus in the form of soluble dimers, DJ-1 is a recognized Parkinson′s disease (PD)-related protein since its gene mutation leads to the early onset of autosomal recessive PD. Under oxidative stress which is closely related to the pathogenesis of PD, DJ-1 exerts its neuroprotective effects by sensing oxidative stress, changing gene expression, and participating in the regulation of AKT, ASK and other important signaling pathways.

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QI Ting-Ting, LIN Lin, LIU Yun, JIANG Yong. DJ-1 and parkinson′s disease[J]. Progress in Biochemistry and Biophysics,2011,38(4):293-298

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Received:July 30,2010
Revised:October 21,2010
Accepted:
Online: November 05,2010
Published: April 20,2011

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