Lysyl oxidases (LOXs) are a family of anabolic enzymes that function to maintain, heal, and remodel tissue architecture by cross linking the extracellular matrix proteins, collagens and elastins. In a series of studies, LOXs have been considered as a family of multi-functional enzymes, which play an essential role in cell proliferation, cell chemotactical responses and tumor genesis. LOXs have now been implicated in several pathological conditions including connective tissue disease, exfoliation syndrome, disorders of copper metabolism, pelvic organ prolapse and bone disorders, so on. Its biosynthesis, structure characteristics, multi-function and relationship between LOXs and human diseases were summarized.
ZHANG Yan-Jun, JIANG Jia-Huan, XIE Jing, YANG Li, SUNG KL Paul. Lysyl Oxidases Related to Human Diseases[J]. Progress in Biochemistry and Biophysics,2011,38(5):389-399
Copy® 2024 All Rights Reserved ICP:京ICP备05023138号-1 京公网安备 11010502031771号