Interleukin-18(IL-18) is a new member of IL-1 cytokine family and known as IFN-γ-inducing factor previously. An increased secretion of IL-18 is generally a marker for many chronic inflammation and autoimmune disorders, implying its involvement in inflammatory responses. Here, it was showed that IL-18 stimulated the expression of CSF-1 in Jurkat T lymphocytes that might be a manifestation for IL-18 to play its biological functions in inflammatory pathogenesis. The signaling mechanism that contributes to IL-18-induced transcriptional activation of CSF-1 was investigated further. Combined data suggested a MyD88-NF-κB-CSF-1 signal pathway is involved in the up-regulated expression of CSF-1.
XUE Yan, LIU Lin-Lin, HE Fen, JIANG Xue, ZENG Xian-Lu, BA Xue-Qing. IL-18 stimulates CSF-1 expression via MyD88-dependent pathway[J]. Progress in Biochemistry and Biophysics,2011,38(4):311-319
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