State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,College of Veterinary Medicine,Northeast Agricultural University,State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences
This work was supported by grants from The National Natural Science Foundation of China(31072113), The National Natural Science Foundation for Outstanding Young Scholars of China (31222054), State Key Laboratory of Veterinary Biotechnology (SKLVBP201205), and Central Public-interest Scientific Institution Basal Research Fund (2012ZL080)
The host restriction factor Tetherin is an interferon-inducible typeⅡ membrane glycoprotein, and plays a vital role in retroviral life cycle. The unusual topology of Tetherin is important for its antiviral activity. Tetherin restricts viral replication by inhibiting enveloped virus release from the surface of infected cells. However, viruses have evolved different strategies to antagonize the antiviral action of Tetherin. The interaction between Tetherin and its antagonist is species-specific which evidenced a long term co-evolution during the fighting history between host and viruses. In this review, we focus on the current advances in our understanding of the molecular structure and antiviral activity of Tetherin, as well as the mechanism used to conteract Tetherin by its antagonists.
YIN Xin, WEI Ping, WANG Xiao-Jun.Review: Antiviral Activity of The Host Restriction Factor Tetherin[J]. Progress in Biochemistry and Biophysics,2014,41(1):32-40
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