Progress of The Research on Nesprins

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Progress of The Research on Nesprins
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Affiliation:Key Laboratory of Arrhythmias,Ministry of Education Tongji University,Key Laboratory of Arrhythmias,Ministry of Education Tongji University,Key Laboratory of Arrhythmias,Ministry of Education，Tongji University
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Fund Project:This work was supported by grants from The National Basic Research Program of China (973 Program) (2013CB531100), Foundation for Innovative Research Groups of The National Natural Science Foundation of China (81221001), The Major International Joint Research Program Fund of China (81120108004) and Yangfan Project of Tongji University School of Medicine (2012YF05)

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Abstract:

The nuclear envelope spectrin repeat proteins (Nesprins), connecting the nucleus with many kinds of cytoskeleton and/or organelles, play important roles in nucleus and cytoskeleton positioning, power and material transporting between nucleus and cytoplasm, nuclear envelope constructing, cell migrating, anchoring and polarizing. Their discoveries, encoding genes, structural characters, functions and related diseases were summarized in this review, and their further research pulses are also prospected meanwhile.

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ZHAO Chun-Xia, CUI Ying-Yu, CHEN Yi-Han. Progress of The Research on Nesprins[J]. Progress in Biochemistry and Biophysics,2014,41(4):337-344

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Received:April 26,2013
Revised:September 22,2013
Accepted:September 26,2013
Online: April 22,2014
Published: April 20,2014

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