Process Engineering Research Institute of the Chinese Academy of Science,Process Engineering Research Institute of the Chinese Academy of Science,Process Engineering Research Institute of the Chinese Academy of Science,Process Engineering Research Institute of the Chinese Academy of Science
This work was supported by grants from The National Natural Science Foundation of China(51103159, 51203162) and Hi-Tech Research and Development Program of China (2012AA022703, 2012AA020804)
Gene therapy has rapidly emerged as a promising method for the treatment of numerous diseases. However, the intrinsic deficiencies of gene-based drugs, such as enzymatic degradation in the body, poor membrane penetrability and lack of target ability, have limited the development of its therapeutic application. Herein, it is important for efficient gene therapy to develop efficient and safe gene vectors that can deliver the gene-based drugs to targeted cells. This paper reviews the current development in gene delivery vectors, especially summarizes the characteristic and development of viral vectors, non-viral vectors and nanoparticles with tracing ability.
LI Yan, YANG Jun, LIU Gui-Ying, ZHANG Xin.Review: The Advance of Gene Delivery Vectors[J]. Progress in Biochemistry and Biophysics,2013,40(10):998-1007
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