College of Optoelectronic Engineering, Shenzhen University,School of Medicine, Shenzhen University,School of Medicine, Shenzhen University,School of Medicine, Shenzhen University,Shenzhen Center for Disease Prevent and Control,School of Medicine, Shenzhen University,School of Medicine, Shenzhen University,College of Optoelectronic Engineering, Shenzhen University,College of Optoelectronic Engineering, Shenzhen University
This work was supported by grants from The National Basic Research Program of China (2012CB85802), The National Natural Science Foundation of China (61235012), The Natural Science Foundation of Guangdong Province (S2011010001223), The Technological and Scientific Innovation Project of Guangdong Educational Commission(2012KJCX0094) and The Scientific Research Starting Foundation for Returned Overseas Chinese Scholars
The quantum dots (QDs) will have biological function by surface modification with biomolecules or drug molecules. The functionalized QDs have been widely applied in biomedical optical diagnosis and therapy for their unique optical propriety and biocompatibility. This paper introduced the synthesis and modification methods of functionalized QDs, and summarized their applications for tumor in vivo diagnosis and therapy, including in vivo lymph node imaging, blood vessel dynamic imaging, tumor imaging and anti-tumor drug tracking, et al. Finally, we also discussed the perspective and the challenge of the functionalized QDs utilization for the tumor in vivo diagnosis and therapy.
ZHU Xiao-Mei, WANG Xiao-Mei, ZHAI Peng, FENG Gang, LIN Gui-Miao, CHEN Qiang, MEI Shu-Jiang, NIU Han-Ben, XU Gai-Xia.Review: Applications of Functionalized Quantum Dots in Tumor in vivo Imaging[J]. Progress in Biochemistry and Biophysics,2013,40(10):963-970
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