Department of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Science and School of Peking Union Medical College,Department of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Science and School of Peking Union Medical College
This work was supported by a grant from National Basic Research Program of China (2013CB967202)
Cancer stem cells have been suggested to play key role in tumor relapse, drug-resistance and metastasis. Chronic inflammatory states have been associated with an increased risk of malignancy. Therefore, it is possible that cytokines associated with chronic inflammation, such as IL-6, IL-8 and EGF, regulate the self-renewal of cancer stem cells via NF-κB/ Stat3 pathways. In this review, we will discuss how these adaptive processes potentially become subverted to enhance the development and function of cancer stem cells.
CHEN Chong, LUO Yun-Ping.Review: Chronic Inflammation and Cancer Stem Cells[J]. Progress in Biochemistry and Biophysics,2014,41(1):52-57
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