Review: Advances on Molecular Mechanism of Chronic Inflammation-driven Lung Cancer Induced by Environmental Carcinogens

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Review: Advances on Molecular Mechanism of Chronic Inflammation-driven Lung Cancer Induced by Environmental Carcinogens
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Affiliation:Zhejiang Provincial Key Laboratory for Technology Application of Model Organisms,School of Life Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,China,325035,Zhejiang Provincial Key Laboratory for Technology Application of Model Organisms,School of Life Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,China,325035,Zhejiang Provincial Key Laboratory for Technology Application of Model Organisms,School of Life Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,China,325035,Zhejiang Provincial Key Laboratory for Technology Application of Model Organisms,School of Life Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,China,325035,Zhejiang Provincial Key Laboratory for Technology Application of Model Organisms,School of Life Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,China,325035,Zhejiang Provincial Key Laboratory for Technology Application of Model Organisms,School of Life Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,China,325035,Zhejiang Provincial Key Laboratory for Technology Application of Model Organisms,School of Life Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,China,325035,Zhejiang Provincial Key Laboratory for Technology Application of Model Organisms,School of Life Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,China,325035
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Fund Project:This work was supported by grants from The National Natural Science Foundation of China (9102970, 81229002)

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Abstract:

Air pollution from rapid industrialization in China and cigarette smoking led to increased environmental exposure to carcinogens, such as Benzo(a)pyrene (B[a]P), nickel, arsenic, can increase the risk for lung cancer. And lung cancer has replaced liver cancer as the leading cause of death among the patients with malignant tumors in China. According to recent studies, carcinogens play major roles in the development of lung cancer and chronic inflammation mediates the carcinogenesis partly. Carcinogen exposure could activate the transcription factor such as NFAT, NF-κB, AP-1 that will enhance inflammation factor transcription and then increase their release. Moreover, this process will be promoted by creating a positive regulatory loop due to sustained activation of transcription factor from the stimulation of inflammation factor release. The chronically inflammational microenvironment induced by carcinogen will cause the initiation and development of lung cancer. The review summarizes the cellular and animal evidences linking chronic inflammation induced by environmental carcinogens to lung cancer.

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LV Jian-Wei, ZHANG Min, JIN Hong-Lei, ZHU Jun-Lan, WEI Jin-Long, DAI Jia, HUANG Hai-Shan, GAO Ji-Min.Review: Advances on Molecular Mechanism of Chronic Inflammation-driven Lung Cancer Induced by Environmental Carcinogens[J]. Progress in Biochemistry and Biophysics,2014,41(1):41-51

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Received:August 22,2013
Revised:November 23,2013
Accepted:December 19,2013
Online: January 23,2014
Published: January 20,2014

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