Review: Epigenetic Regulation in Stem Cell Aging

Home > Archive>Volume 41, Issue 3, 2014 >231-237

Review: Epigenetic Regulation in Stem Cell Aging
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Affiliation:NationalLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences,NationalLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences,NationalLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences,NationalLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences,NationalLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences
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Fund Project:This work was supported by grants from The Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020312) and The National Natural Science Foundation of China (31222039, 81330008)

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Abstract:

Tissue and organ-specific adult stem cells degenerate progressively with age, resulting in compromised tissue homeostasis and occurrence of aging-associated diseases. Epigenetic mechanisms play a key role in controlling individual as well as stem cell aging by the regulation of global and/or specific gene expression. Here, we summarize the recent findings on how epigenetic modifications especially DNA methylation and histone modifications regulate stem cell fate during aging, which may open a promising avenue towards achieving the goal of healthy aging.

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YUAN Ting-Ting, YANG Ji-Ping, GUAN Di, DING Zhi-Chao, LIU Guang-Hui.Review: Epigenetic Regulation in Stem Cell Aging[J]. Progress in Biochemistry and Biophysics,2014,41(3):231-237

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Received:December 19,2013
Revised:December 19,2013
Accepted:December 20,2013
Online: March 24,2014
Published: March 20,2014

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