Structural Basis for Methyl DNA Readout by MBD and SRA Domains

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Structural Basis for Methyl DNA Readout by MBD and SRA Domains
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Affiliation:Institute of Biophysics, Chinese Academy of Sciences,Institute of Biophysics, Chinese Academy of Sciences
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Fund Project:This work was supported by grants from The National Natural Science Foundation of China (31370734, 31430018) and National Basic Research Program of China (2015CB856202)

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Abstract:

DNA methylation at the 5 position of cytosine is one of the most important epigenetic modifications in vertebrate, which regulate gene expression in conjunction with specific protein readers to readout the methyl marks. This review focuses on two major classes of methyl DNAreaders, MBD and SRA domains, and discusses their structural bases and molecular mechanisms of recognizing different types of DNA modification marks.

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YANG Na, XU Rui-Ming. Structural Basis for Methyl DNA Readout by MBD and SRA Domains[J]. Progress in Biochemistry and Biophysics,2014,41(10):1063-1074

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Received:October 08,2014
Revised:October 08,2014
Accepted:October 24,2014
Online: October 24,2014
Published: October 20,2014

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