Research Center of Basic Medical Science,Tianjin Medical University,Technical Institute of Physics and Chemistry, Chinese Academy of Sciences,Institute of Semiconductors, Chinese Academy of Sciences,Tianjin Medical University Cancer Institute and Hospital,Technical Institute of Physics and Chemistry, Chinese Academy of Sciences
This work was supported by grants from Key Research Program of the Chinese Academy of Sciences (KJZD-EW-TZ-L03-6), Natural Science Foundation of Tianjin (13JCYBJC23600), The National Natural Science Foundation of China (61078074) and China Postdoctoral Science Foundation (2014M550794)
Circulating tumor cells (CTCs) are shed by primary or metastatic tumors, undergo the epithelial-mesenchymal transition, and enter into the peripheral blood of patients with metastatic cancers. Its critical roles in cancer research and clinical diagnostics are gradually being recognized. The presence of CTCs, especially the number in peripheral blood can not only be used for early diagnosis of cancer but also be used to assess prognosis, and monitor tumor metastasis and recurrence. Microfluidic chip as a high-throughput, miniaturized cell experimental platform has been used in CTCs sorting. In this review, we highlight recent progresses of CTCs capturing of microfluidic chip system and focus on the capture theory, chip structure and capture efficiency of various types of chips. At last, we prospect for the application foreground of microfluidic chip technology in CTCs isolation.
LV Xiao-Qing, LI Lei, CHEN Hong-Mei, CHEN Peng, LIU Jing. Advances in Isolating Circulating Tumor Cells With Microfluidic Chips[J]. Progress in Biochemistry and Biophysics,2015,42(4):301-312
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