Hippo signaling pathway regulates cell proliferation，differentiation and apoptosis and plays a critical role in the tissue development and homeostasis. We identified Hippo/MST1-YAP signaling is involved BMP2-mediated self-renewal of neuron progenitor cells. We also found MST1 induced neuronal cell death in oxidase stress and c-Abl，a non-receptor tyrosine kinase，function as an upstream regulator of MST1 during the process. Recently，we found MST1 play important role in ischemic stroke induced neuro-inflammation. In this review，we will briefly summarize the significant progress of Hippo signaling in the central nervous system diseases as well as neuronal development.