The looming priority refers to organisms’ prior processing of or greater sensitivity to looming signals . The looming priority has been commonly found in visual, auditory and cross modalities and different kinds of subjects including human and animals. Humanneuroimaging studies suggest that neural substrate associated with the priority involves a massive distributed neural network coordinating and communicating to each other, including the superior temporal sulcus, right temporoparietal junction and some motor areas. The neurons and neural pathways selectively sensitive to looming signals have been found in many kinds of animals. The looming priority is explained from different perspectives, including threatening hypothesis, attentional capture hypothesis and automatic processing hypothesis. Future studies may focus on the role of social and emotional features of looming stimuli and the integration mechanism of multisensory looming stimuli.