Review: Extracellular Matrix and Cancer-associated Fibroblasts

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Review: Extracellular Matrix and Cancer-associated Fibroblasts
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Affiliation:Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
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Fund Project:This work was supported by grants from The National Natural Science Foundation of China (81430067, 31371408) and Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12010100)

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Abstract:

Cancer progression and metastasis are the result of reciprocal interaction between cancer cells and the surrounding stromal components. Tumor stroma features with activation of fibroblasts to cancer-associated fibroblasts (CAFs) and active remodeling of extracellular matrix (ECM) in most solid tumors. CAFs and ECM remodeling are not only characteristics of malignant tumors, but also actively promote tumor progression and metastasis through multiple mechanisms. Strategies targeting CAFs and ECM remodeling may provide novel and powerful approaches in cancer therapeutics.

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GAO Yuan, WU Yue-Xin, HAN Ying-Ying, GE Gao-Xiang.Review: Extracellular Matrix and Cancer-associated Fibroblasts[J]. Progress in Biochemistry and Biophysics,2017,44(8):660-671

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Received:July 03,2017
Revised:July 03,2017
Accepted:July 04,2017
Online: August 16,2017
Published: August 20,2017

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