1
Review: Research Progress of Glycoconjugates on Extracellular Vesicles
Received:July 05, 2017  Revised:August 07, 2017
Key words:extracellular vesicles, exosomes, glycoconjugates, disease diagnose
Fund:国家自然科学基金资助项目(81672537)
Author NameAffiliationE-mail
XU Xiao-Qiang Key Laboratory of Carbohydrate Chemistry & Biotechnology Ministry of Education, Jiangnan University, Wuxi 214122, China 1261598558@qq.com 
GUO Jia Key Laboratory of Carbohydrate Chemistry & Biotechnology Ministry of Education, Jiangnan University, Wuxi 214122, China  
GUAN Feng Key Laboratory of Carbohydrate Chemistry & Biotechnology Ministry of Education, Jiangnan University, Wuxi 214122, China fengguan@jiangnan.edu.cn 
Hits: 1291
Download times: 3025
Abstract:
      Extracellular vesicles (EVs) are a kind of membrane-bound particles with diameters ranging from 20 to 1 000 nm which can be uptaken by recipient cells. More and more research have focused on biological functions of EVs in disease diagnose, prognosis and drug delivery. It has been proved that EVs participate in cell-cell communication and material transfer directly. Nucleic acids(mRNA, microRNA and lncRNA)and proteins contained in EVs have significant influences on the behaviors of target cells. The surface of EVs is covered by glycoconjugates such as proteoglycans, glycosphingolipids and glycoproteins. And these glycoconjugates are directly associated with cell-cell adhesion, cell-cell communication, cell-matrix interactions, immune modulation, metastasis formation and others. This review summarizes the recent research progress of glycoconjugates on Evs, and is helpful to extensively understand the effects of glycosylation in the process of EVs’ biosynthesis, release and transport and EVs’biological functions.
Download PDF  View/Add Comment  Download reader
  
©:Progress in Biochemistry and Biophysics
Responsible Institution:中国科学院Organizers:Institute of Biophysics, The Chinese Academy of Sciences; Biophysical Society of ChinaAddress:15 Datun Road, Chaoyang District,Beijing 100101,China
Tel:010-64888459Email:prog@sun5.ibp.ac.cn
Support:Beijing E-Tiller Co.,Ltd.