Review: Modifications of Tumor Microenvironment by DNA Virus Onco-Proteins
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Center for Molecular Medicine, Central South University,Center for Molecular Medicine, Central South University,Center for Molecular Medicine, Central South University,Center for Molecular Medicine, Central South University

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This work was supported by grants from National Basic Research Program of China (2013CB967203) and The National Natural Science Foundation of China(81530084)

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    Abstract:

    Human viral oncogenesis is a complex process with the multistep nature of oncogenesis. Tumor micro-environmental factors including immune cells and cytokines contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. Interaction between oncoproteins and tumor microenvironment (TME) usually leads to immune suppression, thereby promoting cancer development. In this review, current status and perspectives of the research field in the impact of oncoviral proteins on TME are discussed, including Epstein-Barr virus (EBV), high-risk human papilloma viruses (HPVs), and hepatitis B virus (HBV) respectively.

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HE Jun-Ju, LI Zhi, FU Shu-Jun, SUN Lun-Quan.Review: Modifications of Tumor Microenvironment by DNA Virus Onco-Proteins[J]. Progress in Biochemistry and Biophysics,2017,44(8):678-687

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History
  • Received:July 10,2017
  • Revised:July 10,2017
  • Accepted:July 12,2017
  • Online: August 16,2017
  • Published: August 20,2017