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Review: The Role of Glycosyltransferase Superfamily in Tumor Metastasis
Received:July 27, 2017  Revised:September 11, 2017
Key words:sialyltransferase, fucosyltransferase, N-acetylglucosaminyltransferases, tumor metastasis
Fund:国家重点基础研究发展计划(2012CB822103)和国家自然科学基金(31470799)项目资助
Author NameAffiliationE-mail
CHEN Xi-Xi School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, China tornado_cxx@sina.com 
WANG Li-Ping Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian 116044, China wangliping910205@163.com 
YU Wen-Jing Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian 116044, China wenj_y@163.com 
WANG Han-Yu Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian 116044, China 2216185957@qq.com 
WANG Shu-Jing Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian 116044, China wangshujing@dmu.edu.cn 
ZHANG Jia-Ning School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, China jnzhang@dlut.edu.cn 
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Abstract:
      Protein glycosylation modification includes N-linked glycosylation, O-linked glycosylation and glycosylphosphatidylinositol anchor glycosylation. Difference from nucleic acids and proteins, the synthetic process of glycans is mainly completed by a series of glycosyltransferases which catalyze glucosidic bond, not followed the traditional central dogma of genetic information transmission. Abnormal glycosylation modification is considered to be closely related to the occurrence, development and clinical prognosis of malignant tumor. Previous studies have shown that the abnormity of glycosyltransferases expression and glycans structure affects key steps of the metastatic cascade, such as epithelial-mesenchymal-transition (E-cadherin, N-cadherin) , cell motility (integrin β1 and α5), invasion (matrix-metalloproteinases), extravasation (sLex and sLea), which by regulating the interaction between tumor cells and extracellular matrix. In this review, we mainly focus on the structures and biological functions of three glycosyltransferase families (sialyltransferases, fucosyltransferases and N-acetylglucosaminyltransferases), and their roles in tumor metastasis, hoping it can provide new ideas for the prognosis and diagnosis in tumor metastasis.
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©:Progress in Biochemistry and Biophysics
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