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Review: Complement and Glycosylation
Received:August 01, 2017  Revised:September 18, 2017
Key words:complement, glycosylation, glycoprotein, regulation, factor H
Fund:陕西省自然科学基金重点项目(2016YFJZ0020),国家自然科学基金面上项目(81470548)资助
Author NameAffiliationE-mail
ZHAO Fei Leibniz Institute for Natural Product Research and Infection Biology, Jena 07745, Germany
The Second Affiliated Hospital, School of Medicine, Xi′an Jiaotong University, Xi′an 710004, China 
feizhao821@outlook.com 
DANG Liu-Yi Department of Molecular Biotechnology, Ghent University, Ghent 9000, Belgium  
ZHAO Xuan The Second Affiliated Hospital, School of Medicine, Xi′an Jiaotong University, Xi′an 710004, China
Shangluo Central Hospital, Department of Clinical Laboratory, Shangluo 726000, China 
 
LI Ke The Second Affiliated Hospital, School of Medicine, Xi′an Jiaotong University, Xi′an 710004, China ke.li@mail.xjtu.edu.cn 
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Abstract:
      Complement system is an essential part of the innate immunity which serves as a bridge between innate and adaptive immunity. The complement system comprises of over 30 different proteins, most of which are glycoproteins. The recent researches have shown that complement system plays important roles in defense against the evading microbes and maintaining the cellular hemostasis. However, the complement system requires firm controls. Either insufficient activation or over-activation of complement would cause diseases. In this review, we summarize the recent advances in understanding the activation, regulation and the function of complement system and for the first time review the complement system by its glycosylation: we summarize the glycan structures of the complement proteins and analyze the glycosylation impact on the function of the proteins.
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