Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University; CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University; CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University; CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University,Key Laboratory for Nanomedicine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University,CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen

This work was supported by grants from The National Natural Science Foundation of China (21375141, 81401509, 81371679, 21404115, 81401520 and 21701033), Key International S&T Cooperation Project (2015DFH50230), Natural Science Foundation of Guangdong Province (2017A030313079, 2017A030313726), Dongguan Project on Social Science and Technology Development (2015108101019), Chinese Postdoctoral Project (2017M612803) and Science Foundation of Guangdong Medical University (M2016006)