Department of Biomedical Engineering,College of Engineering and Applied Sciences,Collaborative Innovation Center of Chemistry for Life Sciences,Nanjing National Laboratory of Microstructures,Nanjing University,Nanjing,Department of Biomedical Engineering,College of Engineering and Applied Sciences,Collaborative Innovation Center of Chemistry for Life Sciences,Nanjing National Laboratory of Microstructures,Nanjing University,Nanjing,Department of Biomedical Engineering,College of Engineering and Applied Sciences,Collaborative Innovation Center of Chemistry for Life Sciences,Nanjing National Laboratory of Microstructures,Nanjing University,Nanjing,State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,Department of Biomedical Engineering,College of Engineering and Applied Sciences,Collaborative Innovation Center of Chemistry for Life Sciences,Nanjing National Laboratory of Microstructures,Nanjing University,Nanjing
This work was supported by grants from The National Natural Science Foundation of China (21722503, 21405081), National Basic Research Program of China (2015CB659400), PAPD Program, Shuangchuang Program of Jiangsu Province, Open Funds of the State Key Laboratory of Analytical Chemistry for Life Science (SKLACLS1704), and Thousand Talents Program for Young Researchers
Nanozymes, the catalytic nanomaterials with enzyme-like properties, have attracted enormous interests in recent years. They have been used for wide range applications from biosensing and bioimaging to therapeutics and environmental protection. In this review, we highlighted the recent progress of nanozymes in analytical applications. We first discussed the in vitro applications, which covered the detection of bioactive small molecules, nucleic acids, protein biomarkers, cells, etc. We then discussed the in vivo applications, which included the monitoring of bioactive small molecules in live brains and tumor tissues, the study of drug efficacy, and the investigation of drug and nanozyme metabolism, etc. Finally, we concluded the potential challenges of nanozymes when applying to analytical chemistry and prospected future directions.
LI Si-Rong, HUANG Yen-Chun, LIU Jia-Rui, WANG Er-Kang, WEI Hui.Reviews and Monographs: Nanozymes in Analytical Chemistry: From in vitro Detection to Live Bioassays[J]. Progress in Biochemistry and Biophysics,2018,45(2):129-147
Copy® 2024 All Rights Reserved ICP:京ICP备05023138号-1 京公网安备 11010502031771号