Institute of Cardiovascular Disease,Key Lab for Atherosclerology of Hunan Province,University of South China,Hengyang,Institute of Cardiovascular Disease,Key Lab for Atherosclerology of Hunan Province,University of South China,Hengyang,Institute of Cardiovascular Disease,Key Lab for Atherosclerology of Hunan Province,University of South China,Hengyang
This work was supported by grants from The National Natural Science Foundation of China (81070221) and the Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province and the Construct Program of the Key Discipline in Hunan Province (15C1201)
Autophagy is an evolutionarily conserved cellular degradation program. Abnormalities in autophagy are directly linked to human ailments. In the cardiovascular system, autophagy is essential for maintaining normal contraction and conduction at low basal levels under physiological conditions. Meanwhile, under pathological conditions, such as ischemia/reperfusion injury and heart failure, autophagy is enhanced. Accumulating evidence shows that microRNA plays a crucial role in autophagy in the cardiovascular system, including cardiac development, maintenance of normal physiological functions, and in different cardiovascular diseases (CVDs). In this review, we highlight the recent advances in the understanding of the relationship between microRNAs and the related autophagic regulation in CVDs. It is expected to provide a new direction for the diagnosis and therapy of CVDs.
ZENG Zhao-Lin, CHEN Jiao-Jiao, WANG Zuo. microRNAs Act as Regulators of Autophagy in Cardiovascular Disease[J]. Progress in Biochemistry and Biophysics,2018,45(11):1115-1125
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