Institute of Biochemistry and Molecular Biology,Medical School of Ningbo University,Institute of Biochemistry and Molecular Biology,Medical School of Ningbo University,Institute of Biochemistry and Molecular Biology,Medical School of Ningbo University
This work was supported by grants from the Natural Science Foundation of Zhejiang Province (LQ18H200001), the Non-profit Technology Research Program of Zhejiang Province (LGF18H160006), the Natural Science Foundation of Ningbo (2017A610247), the Scientific Innovation Team Project of Ningbo (2017C110019), the National Undergraduate Training Program for Innovation and Entrepreneurship(201711646018) and the K.C. Wong Magna Fund in Ningbo University
Long non-coding RNA (lncRNA) is involved in various physiological and pathological processes of tumors. Studies have shown that lncRNAs can participate in gene expression regulation by interacting with microRNA (miRNA) response elements (MREs) and forming a competitive endogenous RNA (ceRNA) regulatory network with other RNA molecules. The lncRNA plays an important role in non-small cell lung cancer (NSCLC) development via ceRNA function. It provides valuable insights into the molecular mechanism of NSCLC and novel targets for precision medicine of NSCLC. This review is based on our previous discovery of lung cancer-related ceRNAs and focuses on the role of lncRNA by acting as highly/lowly expressed and therapeutic ceRNAs in NSCLC.
PAN Jin-Chang, MENG Xiao-Dan, GONG Zhao-Hui. The Role of lncRNA as Competitive Endogenous RNA in Non-Small Cell Lung Cancers[J]. Progress in Biochemistry and Biophysics,2018,45(11):1126-1135
Copy® 2024 All Rights Reserved ICP:京ICP备05023138号-1 京公网安备 11010502031771号