Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Pharmaceutical College of Henan University, Kaifeng Henan 475004, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China,Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China

This work was supported by grants from The National Natural Sciences Foundation of China (81503106, 81773288, 81173633) and National Health Commission for Significant New Drugs Development (2018ZX09201001-001-004)