Department of Rehabilitation, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China
This work was supported by a grant from The National Natural Science Foundation of China (81572219).
Poly(A) binding protein (PABP) family is commonly considered a protective barrier for the mRNA poly(A) tail. As a member of PABP family, cytoplasmic poly(A) binding protein-1(PABPC1) binds to A-rich mRNA sequences with high affinity and plays an important role in the post-transcriptional regulation. In addition, PABPC1 also participates in many metabolic pathways of mRNA, including polyadenylation/deadenylation, mRNA transport, mRNA translation, degradation and microRNA-associated regulation. Recently, numerous studies demonstrate that PABPC1 associated with the growth of germ cells, the hypertrophy of myocardium and the development of tumors, suggesting a close relationship between PABPC1 and the growth and development of cells. In this review, we will mainly summarize the structure, expression regulation, function and biological function of PABPC1.
YAN Zhi-Peng, ZENG Ni, WU Di, NI Guo-Xin. The Functional and Biological Effect of The RNA-Binding Protein PABPC1[J]. Progress in Biochemistry and Biophysics,2019,46(6):545-554
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