Progress on Function of Atg11
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1.College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China;2.National Key Laboratory of Wheat and Maize Crop Science, Zhengzhou 450001, China

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This work was supported by grants from Natural Science Project of Henan Science and Technology Department (162300410175), National Engineering Laboratory for Wheat & Corn Further Processing, Henan University of Technology (NL2016011) and Fundamental Research Funds for the Henan Provincial Colleges and Universities in Henan University of Technology (2016QNJH20).

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    Abstract:

    Atg11, as scaffold proteins, mainly mediated the formation of autophagosome in selective autophagy through its many helical domains. Selective autophagy could specifically remove damaged biomolecules and organelles and played an important role in the intracellular material turnover of eukaryotes. Firstly, the structural features of Atg11 were briefly introduced. Secondly, the roles of Atg11 in three kinds of selective autophagy including Cvt pathway, peroxidase autophagy and mitochondrial autophagy were introduced. Finally, the other features of Atg11 were briefly summarized. This review systematically summarized the research progress of Atg11 in recent years, so as to provide references for the formation of autophagosomes and the function of Atg11 in this process.

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SHAN You-Tian, GU Ze-Wei, KONG Zhen, ZHOU Ye, LI Bing, YAN Ming-Fang, WANG Ying-Ying, CHEN Yi-Ran, JING Hong-Juan. Progress on Function of Atg11[J]. Progress in Biochemistry and Biophysics,2019,46(8):796-803

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History
  • Received:October 25,2018
  • Revised:June 11,2019
  • Accepted:July 12,2019
  • Online: November 05,2019
  • Published: August 20,2019